Dul ma woko pa fungi man bacteria, ma julwongo ni "extracellular matrix" nyo ECM, utiye ku kit jelly man etiwu calu dul ma gwoko man adila. Ento ni lubre ku somu manyen i gazeti iScience, ma jutimo ku University of Massachusetts Amherst ku kony pa Worcester Polytechnic Institute, ECM pa lei moko ma nok timo gel kende kende ka oxalic acid nyo acid mange ma yot utiye. Pien ECM timo tic ma pire tek i lembe ceke nicaku ikum rwom pa yath ma jwigo two nitundu ikum paip ma ucungo man ikum jam tic mi yath, nyang ikum kite ma microorganisms tiyo kudu ku gel layers migi ma ucungo ikumgi utiye ku tic madit ikum kwo mwa ma kubang ceng.

"Abedo ku miti ikum ECMs pa microbial," Barry Goodell uwacu, japonji mi microbiology i University of Massachusetts Amherst man jagor madit mi waraga. "Dhanu pol kare giparu niya ECM ubedo piny ma gwoko kum ma gwoko lei makwiny. Ento ecopu bedu bende ni yore mi tero cam man enzymes i iye man woko kud i cell pa lei makwiny."
Jam umu ne timo tic madwong: bedo moth pare nyutho nia lei makwiny acel acel copo cokiri karacelu mi yubu colonies nyo "biofilms", man ka lei makwiny mapol gitimo eno, ecopu juku paip nyo nyayu two i jam tic mi yath.
Ento adila ucikere ni bedu ma pii pii: lei makwiny mapol wodhu enzymes matung tung man metabolites mange kud i ECM, i piny ma gimito camu nyo nyayu two (macalu yen ma otho nyo adila pa lei ma cogo), man i ngeye, ka enzymes udaru timo tic migi, tic mi nyayu cam – dwoko cam kud i ECM.
Eni nyutho nya ECM epe kende kende piny ma gwoko kwo; I andha, calu Goodell ku juwadi ginyutho, microorganisms nen calu gitiye ku copo mi doro viscosity pa ECM migi man kumeno permeability pare. Gitimo nenedi?
I fungi, piny ma wok kud i iye nen calu oxalic acid, acid ma nwangre i lum mapol, man, calu ma Goodell ku juwadi ginwangu, piny ma nok nok nen ni tiyo ku oxalic acid ma giwodho pi maku piny ma woko pa carbohydrates. timo piny ma mako. , ECM ma calu jelly.
Ento kinde ma jutic ne gineno maber, ginwangu niya oxalic acid ukonyo ngo kende kende ni yubu ECM, ento de "etimo" ikume: ka oxalic acid madwong ma microbes umedire i carbohydrate-acid mixture, ECM doko tek. Ka ECM doko tek, edoko tek ni juku molecule madongo ni mondo nyo niwok kud i microbe, ento molecules ma nok bedo agonya ni mondo i microbe kud i kabedu man kumeno bende.
Lembe ma junwango eni nyayu lembe ikum nyang pa ju ma gisomo lembe macon ikum kite ma kit piny matung tung ma wok kud i fungi man bacteria wok kud i piny ma nok nok eno i kabedu. Goodell ku juwadi giwacu niya i kare moko, lei makwiny copo bedu ku gen ikum poko pa molecule ma nok pi nyayu ret ikum matrix nyo tissue ma lei makwiny tiye kudu pi kwo nyo nwangu two. Eni nyutho nya wodhu pa molecules ma nok copo bedu ku tic madit i pathogenesis ka enzymes madongo copo kadhu kud i extracellular matrix pa microbial.
"Nen ni lembe moko tiye ikind," Goodell uwacu, "ma microorganisms copo jwigo rwom pa acidity ni bedo i kabedu moko, ma gwoko molecule moko madongo, calu enzymes, man weko molecules ma nok kadhu kud i ECM. "Modulation pa ECM ku oxalic acid copo bedu yore ma microorganisms copo gwoko gi kud i kum antibiotics, man antibiotics pi en pol pa yath eni gitiye ku molecule madongo. Etiye kero mi loko piny ma copo bedu yore madit mi loyo acel ikin peko madongo i yath mi jwigo kwidi, calu loko ECM mi weko ebed yot copo medo tic pa yath mi jwigo kwidi man yath.

"Ka wacopo jwigo biosynthesis man secretion pa acid ma nok calu oxalate i microbes moko, ci wacopo bende jwigo gin ma cidho i microbes, ma copo konyowa ni daru two mapol ma wok kud i microbes," Goodell uwacu.
I Dwi mir apar wi aryo 2022, jagor Yasu Morita unwangu kony kud i bang National Institutes of Health pi konyo tic mi sayu lembe ma jutimo pi yubu yore manyen, maber pa yath pa two thwol.

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