Adwogi pa somo pa dul pa dhanu moko kud i Shanghai Jiaotong University nyutho nia formic acid ubedo piny ma pire tek ma copo nyutho two Alzheimer's (AD). Lembe ma junwango copo yabo yo pi timo sayusac ma yot man ma yot. Daktari Yifan Wang, Daktari Qihao Guo man juwadi gi goyo lembe moko ma julwongo niya "Systematic Evaluation of Formic Acid in Urine as a New Potential Alzheimer's Biomarker" in Frontiers in Aging Neuroscience. I lembe migi, ju goro gi daru kumae: "Formic acid i lac utiye ku rwom maber mi ngiyo two Alzheimer con... Nwangu biomarkers pa two Alzheimer i lac utiye yot man ber. Umitu juketh i lembe mi yath pa judongo."
Ju ma goro buku ne giweco ni AD, kit two ma dhanu mapol maru, nyutre ku goro pa wic man kura pa dhanu. Lembe madongo ma nyayu two AD uketho i iye rwom ma rac pa amyloid β (Aβ), rwom ma rac pa neurofibrillary tau tangles, man ret pa synapse. Ento, dul ne umediri, "thek pa AD ungeyere ngo maber."
Twoyo pa Alzheimer copo bedu ma dhanu ungiyu ngo nitundu edaru nwangu yath. "Etiye two ma rii pi kare malac man ma rii pi kare malac, ma nyutho nya ecopu dongo man rii pi oro madwong mapodi peko mi wic unen ungo," ju goro gi uwacu. "Kit ma two ne caku kudu wok mapodi kare pa two wic ma rwinyo ngo, ma en e dirisa maber pi kony man yath. Pieno, timo sayusac madit pi two Alzheimer i acaki pa dhanu ma oro migi cidho malu piretek."
Kadi bed ni yub mi ngiyo two konyo ni nwangu two ne con, yore mi ngiyo two ma kawoni utiye matek man tek pi ngiyo two ne. Positron emission tomography-computed tomography (PET-CET) copo nwangu Aβ con, ento tek man eketho jurutwo bedo i radiation, man biomarker tests ma konyo ni nwangu two Alzheimer mito kwany rimo nyo lumbar punctures pi nwangu cerebrospinal fluid, ma copo bedu repulsive ni jurutwo.
Ju ma timo sayusac gineno nia lembe madwong unyutho nya ecopu bedu yot ni ngiyo jurutwo pi lanyuth pa AD. Urinalysis epe ku remo man yot, ma weko etiye ber pi pimo dhanu madwong. Ento kadi nang ju ma gisomo lembe mi ngec gilar ginwangu biomarkers mi lac pi AD, acel de epe maber pi nwangu acaki pa two ne, ma nyutho nya kare maber mi nwangu yath con podi ubedu tek.
Wang ku juwadi gitimo sayusac ikum formaldehyde calu lanyuth pa two Alzheimer. "I kind oro ma ukadhu, tic pa formaldehyde marac ungiyure ni acel ikin the lembe ma nyayu peko mi wic pi oro," giwacu. "Somo mwa mukadho onyuthu dikiri pa kadhiri pa formaldehyde i lac ku tic pa wic, ma nyutho nia formaldehyde i lac ubedo lanyuth ma copo konyowa ni nwangu two AD con."
Ento, kabedo moko utiye mi medo tic ku formaldehyde calu biomarker pi nwangu two con. I lembe migi ma juwodho kawoni eni, dul ne uketho wigi ikum formate, piny ma nyayu remo, ni neno ka etiyo maber calu biomarker.
Udul mi somo ne uketho i iye dhanu 574, ikinde ju ma two Alzheimer's utiye ku peko matung tung, man ju ma kumgi yot. Ju ma timo sayusac gi ngiyo lac man rimo pa ju m'utimo sayusac ni neno tung tung pa lac pa biomarkers man gitimo sayusac mi paru pa dhanu. Ju m'ubedo i tic ne jupoko gi i ungu abic nimakere ku two migi: dhanu 71 ma wic migi ber (NC), dhanu ma wic migi rwinyo (SCD) 101, wic ma rwinyo ngo (CINM), wic ma rwinyo 131, wic ma nok (MCI) 158 dhanu, man 113 ku BA. .
Somo ne unwangu niya kadhiri pa formic acid i lac ubedo malu akeca ikind ju ma twoyo pa Alzheimer man urombo ku rwinyo pa wic ka juporo ku ju ma kum gi yot, ikinde ju ma rwinyo wic migi con. Eni nyutho nia formic acid copo bedu ni lanyuth ma pire tek pi acaki pa AD. "I lembe maeni, wabe nyutho pi tyen acel nia kadhiri pa formic acid i lac lokore ku rwinyo pa wic," giwacu. "Acidi mi lac unyutho tic maber mi nwangu two AD. Mi medo, asidi mi lac umedire lee ikind ju ma jutimo igi yath pa SCD, ma nyutho ni acid mi lac copo tiyo pi nyang two AD con."
Ber pa lembe, kinde ma ju ma timo sayusac gi ngiyo kadhiri pa formate i rimo ku lanyuth pa two Alzheimer, ginwangu niya gicopo tito rwom pa two ne i dhanu. Ento, lembe mukende mitere pi nyang ikum dul pa two Alzheimer ku formic acid.
Ento, ju ma goro buku gi daru: "Kit pa formate ku formaldehyde i lac copo bedu ngo kende kende ni poko kind AD ku NC, ento bende ni medo rwom pa plasma biomarkers pi rwom pa two AD. biomarkers ma copo bedu pi nwangu two".